Mežotne Palace is a palace in the historical region of Zemgale, in Latvia, Bauska region (former Mežotne municipality in Bauska district). The palace suffered heavily in the First and later in the Second world war.
Built in Classicism style during 1798-1802 for a teacher and governess of the grandchildren of Russian Empress Catherine II, Charlotte von Lieven (1742–1828). Architects of the palace were famous Italian Giacomo Quarenghi and Johann Gottfried Adam Berlitz, architect of the Durbe Manor and the Kazdanga palace. Both Kazdanga and Mežotne palaces have many similarities in form. Simultaneously with the palace there has also been developed an English style landscape park and complex of subsidiary buildings, creating one of the most impressive Classicism style ensembles in Latvia.
The Lieven family owned the palace up to agrarian reform in 1920. Palace and park underwent reconstruction in 2001 and since then a hotel is located there.