Melissani Cave (Greek: Μελισσάνη) or Melissani Lake, also Melisani is a Greek cave located northwest of Sami, about 5 km SE of Agia Efthymia, NE of Argostoli and NW of Poros. The Ionian Sea lies to the east with the Strait of Ithaca. Forests surrounds the cave and the mountain slope is to the west. Near the cave is the entry to the cave with parking lots and is passed almost in the middle of the main road linking Sami and Agia Efimia especially to the northern part of the island.
In Greek mythology, Melissani was the cave of the nymphs. The cave features a lake that are surrounded with trees and forests. The cave is located east of the mountains of Evmorfia and Agia Dynati. Tourism is common in the cave.
The cave features a sky-blue lake covered with stones at the bottom. the depth is thin. Plants are at the door of the cave. The color of the rocks which are stucco to honey-like brown is at the door of the cave. The lake is also inside the cave.
The cave was rediscovered in 1951 by Giannis Petrocheilos.
In 2004, chef Mamalakis for his cooking show on Mega visited Melissani along with other places in search for cuisine on Kefalonia.