The palace is an impressive construction of coralline blocks that once housed some fifty rooms and a number of gardens and courtyards, although what remains today is about half the size it once was. It was built under Diego Colón, the son of Christopher Columbus; when he became Viceroy of La Española and the Indies in 1509, he ordered the construction of a family home and governor’s mansion between 1510 and 1512.
During the early Spanish colonial period, the mansion occupied a very important place in history. It was from here that many expeditions of conquest and exploration were planned. In 1586, the palace was sacked by Sir Francis Drake and his forces. As the influence of Santo Domingo waned, the house fell into ruins, and by the mid-18th century was abandoned and in danger of rotting away. It was rescued and extensively restored between 1955 and 1957, being filled with period furniture, artwork, and other accessories. A self-guided tour using a portable audio speaker that discusses each room's function is available in various languages.
- Colonial City of Santo Domingo